[转贴]李承鹏：成龙为什么不憎恨

成龙很久没拍过好的电影了，无需拍，因为现在他本身就是一部好的电影。从“中国人确实需要管一管了”到向菲律宾伸手“友谊之手”，他完成人生演技最重大的一次提升，演得太好了，下一步只有出演特首才承受得了。



我并不同意因为自己人被欺负，就要派解放军去轰炸菲国把菲佣弄到大巴上一一击毙最好把东南亚全部解放了，一是因为那儿不归我们解放，我们只有更加文明才不会被野蛮欺负，用野蛮对付野蛮只有更加野蛮（比如非洲有些地方现在还杀来杀去），再就是，如果中国人被欺负就要轰炸，就得轰炸强拆过中国商人店铺的某某国还要轰炸让中国民工淹死在海滩上的某某国更要轰炸把两个中国商人活活打死的某某国，这要花费太多的炸弹……当然，这样的报道经常是被屏幕了的，因为我们必须是大国，小民，而大国。



但成龙说“如果警方一开始就击毙绑匪，人们会说怎么不谈判？如果警方先谈判，人们又会说怎么不一枪击毙”，我估计好多人读到这里咯登一下，因为确实，前段时间幼儿园事件我们曾批评过警方不谈判就崩了没什么实质威胁的劫匪，不人性，这次菲国的例子正好反过来，让你有些无从反驳。从这一点看来，说成龙是霸王洗发水用多了，不仅伤了头皮还伤了脑子，是低估了成龙，成龙是演员中的战斗机，战斗机中的隐形机，他敦厚的外表下面隐藏着很高的智商。这句话居然用上了二元极致的玩法。所以那三条推特儿不是助手随意发上去的，成龙可能随意发推特吗，一个推油都不会随意的巨星，是不会随意推特的。



大家应该觉得成龙这话的句式很眼熟，想一想，就会发现其实就是前两天国资委一位领导说的：现在的老百姓是怎么啦，国有企业不赚钱你们骂，国有企业赚了钱你们还骂，要我们怎么办。明白吧，成龙确实很适合当领导了，都很凛然的句式，但其实是，拿着人民的钱的国有企业不赚钱当然骂，赚了钱却不回报人民或者干脆就不是挣钱而是抢钱，更要骂。回到菲律宾这件事，警方当然不可以不谈判就击毙绑匪，更不可以谈判十来个小时才击毙绑匪。反正我看到营救人质那一队人马时，还以为菲律宾也有民兵编制，或者是协警，后来才知道，他奶奶个腿的居然是特警。



那些悲伤的细节和那些诡异的笑容不想多谈了，有时候回忆也有罪恶感。我只是奇怪当年那个演员怎样变成一个领导的，我想他肯定想当电影局局长甚至想当文化部部长，我承认这样的揣测有些恶意，但现实告诉我们，在中国什么东西做大了，就容易叛变，不要以为内地人才会叛变，港台人也一样，成龙不再是一个演员，而是世博肉身的海宝，是奥运第六个福娃，是一切堂会剪彩的金剪刀，是维持会会长，到最后他觉得中国人确实应该管一管，而政府又管不到位，就该拿给绑匪去管一管吧。



这证明我们这个地方的某种力量足够大，大到足以把一个演员培养成为领导，其实也不一定演员才叛变，知识份子也一样，比如陈文茜前段时间说韩寒不该骂世博会，陈文茜在台湾以犀利著称，现在却当起世博唱诗班BB，可是在上海生活近三十年的韩寒还不比刚来上海三天的陈文茜更了解上海和上海的变化？这就不对，但陈文茜就是要这样说，这样说她有利益——而且这个好处必不是帮李敖炒作李戡……其实李敖也是我们那一代愤青曾经很喜欢的，因为他敢一人独抗国民党反动派和阿扁很多年，但现在他在写《阳痿美国》，在大赞内地日新月异的变化，中国内地当然有很多变化，但你独看到可喜的看不到可忧的，你不再像知识份子那般深独立去反思，而只是随便的起兴，这就不是李敖，而是李咏，不是反骨的李敖，而是看院的藏獒。



利益知识份子，利益演员，利益科学家，在这个强大的气场下，你以为他们唱的是“我们都有一个家”，其实心里是“台币人民币两手都要抓”，你以为他要做龙的传人，其实他要弄翻一船人，你看，凡是成龙代言的产品，最后都死光光，无一例外：代言小霸王，小霸王倒闭了；代言爱多VCD，爱多倒闭、老总坐牢；代言汾湟可乐，汾湟可乐没了；代言开迪汽车，全国才卖九百多辆；代言霸王洗发水，被查出霸王致癌，很快也将消失了。而成龙最新代言的另一品牌格力空调，近期也频传空调爆炸事件，成龙就是一广告毒药，代言谁谁死……这个不是我统计的，是别人，如有出入，请查。



想一想，成龙比郭德纲还要低俗的，郭胖子代言的伪劣广告没成龙多，也没一个小龙女摆在大街上，更没说过不憎恨菲律宾，可郭胖子是要下架的，成龙不会下架，成龙的电影照样放，成龙的堂会照样开，成龙的传人还要薪火相传，可见有关部门比我们都懂成龙，因为成龙比郭德纲还懂中国内地。再想一想，中国人没人管你憎恨，中国人太多自由你憎恨，中国网民乱说话你憎恨，中国记者调查霸王你憎恨，独独中国人被杀死在异国你不憎恨，这多少有点让人憎恨。



我不欣赏民族主义，也不见得就接受自由主义，我只选择人性主义，因为只是一个俗人，只搞得懂最基本的主义。上上篇“中国人为什么没安全感”被战胜了，我并不介意，因为我知道并不因为"安全感" 被战胜，中国人就有了安全感。大家知道，我们没可能改变世界，只有世界改变我们，所以我们需要偶像，因为偶像可以改变心情，带来点安全感，但是，这次人死了，成龙没有声哀鸣，只有声援菲国，这有些怪怪的，老吾老以及人之老，幼吾幼以及人之幼，如果成龙只做到妻吾妻以及人之妻，这就很让人寒心，很没安全感。

From iPSC to induced beta-cells, iN and iCM: dedifferentiation vs direct reprogramming

The success of inducing pluripotency in primary fibroblasts and other cells with a combination of only a small number of transcription factors suggested that fully differentiated cells might change fate following similar treatments. Since the demonstration of induced pluripotent stem cells (iPSCs), at least three examples have been published where 3 cell type-specific factors were selected from a pool of 10-20 candidates that, when expressed from viral vectors, could induce beta-cells, neurons, or cardiomyocytes.

Induced beta-cells [1]: Ngn3, Pdx1, and Mafa, adenovirus injected to in vivo targets

Induced neurons (iN) [2]: Ascl1, Brn2, and Myt1l, lentivirus infecting mouse embryonic fibroblasts (MEF) or tail tip fibroblasts (TTF)

Induced cardiomyocytes (iCM) [3]: Gata4, Mef2c, and Tbx5, lentivirus infecting cardiac fibroblasts or TTF

In all 3 cases, the change of fate seemed to be via direct conversion, without passing through a progenitor cell fate before further differentiation. Like iPSC reprogramming, direct reprogramming also requires a transient supply of inducing factors. Unlike generating iPSCs, the percentage of cells getting reprogrammed is much higher in direct reprogramming, ~20% in the cases of iN and iCM vs 0.1-1% in iPSC. It is likely that a transient, inductive expression of essential factors jump-starts endogenous factors to establish cell fate specific programs; it has also been illustrated that chromatin remodeling through DNA methylation, histone modifications, etc. accompanies the direct reprogramming events.

Read the complete story and this week's official post and new product of the week, weekly promotion, etc, go here.

Do You Know How Well Your Sunscreen Works?

Skin diseases caused by sun exposure include melanoma, basal cell carcinoma, squamous cell carcinoma, photoaging, as well as sunburn and many other conditions. According to the Skin Cancer Foundation, skin cancer is the most common type of cancer in the US. The vast majority of mutations found in melanoma, according to a 2009 study published in Nature [1], are caused by UV radiation.

Currently, commercial sunscreens are composed of physical sunblocks including zinc oxide and titanium dioxide, and chemical UV (ultraviolet lights) absorbers/filters such as octinoxate for UVB and benzophenone for UVA. The compositions of commercial sunscreen products are disclosed by the manufacturer and regulated by the health product regulatory authorities such the FDA in the US. The UV absorbers/filters are organic chemicals that absorb UV lights within a very limited range of wavelength. Consequently, a combination of different chemicals is needed to achieve "broad-spectrum" protection.

Currently the FDA required test of effectiveness of UV protection measures only UVB, which means there is no way of knowing how effective a sunscreen product is against cancer-causing UVA and damaging visible lights [2]. Even though the life style changes in recent time result in more damaging light exposure such as extended sun bathing on beach or tanning in beauty saloons, etc., only 3 new sunscreen active components (and none of new chemical class) have been introduced to the US market in more than 3 decades. There seems to be a gap between the need and the effort for developing substantially improved skin protection products.

For references, see original blog: http://allelebiotech.com/blogs/2010/08/do-you-know-how-well-your-sunscreen-works/

反三俗趣贴，世道不一样了，人也不好忽悠了

A couple of good ones out of thousands of posts related to the current campaing against "3 low tasts/classes" by the gov in China:

枫林晚照:

孤舟蓑笠翁，独钓寒江雪。
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一个老翁在小舟中独吊一个叫寒江雪的少女，证据确凿！以为将吊换成钓俺就看不出来？

hzg7：

花褪残红青杏小
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该禁，这鸟人在抱怨人家飞机场

mstzl518：

衣带渐宽终不悔，为伊消得人憔悴
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这个，又黄又凄美

Looking back at another year

It’s that time again to thank mom, and sit down with a bottle of wine and look back at life, particularly the last year, to see whether it has been good.  Let’s see, still have a couple of true friends, even though our views of world started to differ recently, but we are still true friends as what true friends mean.  Got two boys who so far have been growing up fine, all looking good for them to become good and honorable men.  Two papers in peer-reviewed journals, more than a couple of patents granted and few more filed in the last year alone. Been taking care of dozens of employees and their families, trying to be fair and helpful with everyone involved.  

Yet nothing too dramatic has happened in recent years. Experiencing an 8.9 quake in Chengdu did not feel like anything felt back in 76 during the Tangshan earthquake.  Nothing came close to surpass the experience 11 years ago as major event in life.  It hardened me, like battle field tough, whatever bad happens now could not be as oppressive and unjust as what I had experience then, so it is actually natural to never give in, never give up.  Sometimes I can’t stop wondering what if it all ended then?  Would it be worth it?  Would there be regrets that all the things that happened in the last 11 years would not have had the chances to play out?  Would the world miss my discoveries and contributions?  Probably not, but what about the kids?  I guess hypothetical questions are pointless most of the times, because all optional assumptions are of no real consequences.  Even so, I would say yes to the “worth it” questions, seeing what has occurred to other countries since 89 and their peoples, and what is happening to the tired and the poor of my old country.  Had I died back then, I would have wished that if one day someone would put something like this to the memory of me:

“You did not bear the shame
You resisted
Sacrificing your life
For freedom, justice and honor”

A memorial to von Stauffenberg  and the entire German Resistance  

Since I didn’t become a hero, this should go to those who did sacrifice their lives.  For me, at least I can say, I did not bear the shame.  

MicroRNA-132 is identified as a stimulator of neovascularization

http://www.allelebiotech.com/News//index.php?mod=article&cat=RNAi&article=774

By looking for miRNAs that are upregulated by VEGF or bFGF in umbilical vein endothelial cells (HUVECs) AND an ES neovascularization model, researchers in the Cheresh group at UCSD and Moores Cancer Center and the King lab at U Michigan identified miRNA-132 as a critical switch for activating endothelial cells during angiogenesis. The result, published in Aug 1st’s Nature Medicine, is most significant in that miRNA-132 could become a target for tumor prevention given the relevance of pathological blood vessel formation to tumors.


Profiling of miRNA during pathological development has been fruitful in many cases, including one conducted by Allele Biotech’s researchers and colleagues from Nanjing Medical University where a number of miRNAs were identified with dramatic changes that are specific to several stages of adipogenesis. It is somewhat surprising that miRNA profiling has not been done in more development models or in more systematic ways. In fact, other miRNAs have been identified as stimulators of angiogenesis previously, such as miR-296, which, different from miRNA-132, is “upregulated only in growth factor-treated endothelial cells but not in the developmental angiogenesis screen using human embryonic stem cells.”

The mechanism by which miRNA-132 enhances blood vessel formation has been pinpointed to a RAS regulator. The method used for predicting miRNA targets was by using 3 algorithms for finding multiple sites in the 3’-UTR. The technique for analyzing miRNA-12 effects was mostly based on using an anti-miRNA-132 oligo. Both cell and animal models were used in this study. A type of tumor-specific integrin-targeted nanoparticle was used to deliver anti-miRNA-132 to tumor sites in mice.

Anand et al. Nature Medicine, 08/01/2010
http://www.nature.com/nm/journal/vaop/ncurrent/full/nm.2186.html